The services we offer extend from method development and validation to taking over complete responsibility for release, stability and comparability testing and storage of cell banks in accordance with GMP.
Our cell culture department is specialized in in vitro bioassays and in the development of stable cell lines. By using the ClonePix technology, many clones can be screened within a short amount of time to evaluate a stable, high-expressing clone. This saves tremendous time and costs for our clients.
Bioassays |
- Proliferation
- Differentiation
- Apoptosis
- Cytotoxicity
- Angiogenesis
- Enzymatic assays
- Test for neutralizing antibodies
- VSV-Interferone assay
- Virus-based assays (S1 and S2)
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ELISA |
- Identification and quantification of proteins in different matrixes
(cell culture medium, animal or human serum)
- Detection and quantification of serum antibodies
- Detection of neutralizing antibodies in serum
- Detection and quantification of host cell proteins
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Other immunological methods |
- Complement activation assays
- Western Blot
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Development of stable cell lines |
- Transfection
- Clone selection by using ClonePix
- Amplification
- Adaptation of the cells to serum-free media
- Adaptation of adherent cells to suspension
- Small scale fermentation
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Testing of cell lines with respect to contamination with
the Squirrel monkey retrovirus (SMRV) |
- according to the reference of ZKBS, February 2007 (file no.6790-05-02-37)
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Characterization and stability testing of prokaryotic cell banks |
- Identity (genotype and phenotype)
- Plasmid copy number
- Stability
- Purity
- Viability
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Storage of cell banks (MCB and WCB) in accordance with GMP |
- GMP-qualified instruments
- Nitrogen tanks with restricted access
- Separate containers for prokaryotes and eukaryotes
- Storage in the gas phase of liquid nitrogen (< -130° C)
- Permanent temperature and filling control
- Automatic alarm transmission
- Documentation archived for 15 years
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Our Quality Assurance
