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Brain Res Dev Brain Res. 2004 Jul 19;151(1-2):199-202.

Expression of growth differentiation factor-5 in the developing and adult rat brain.

By: O'Keeffe GW, Hanke M, Pohl J, Sullivan AM.

Expression of the dopaminergic neurotrophin GDF-5 in developing rat ventral mesencephalon (VM) was found to begin at embryonic day (E) 12 and peak on E14, when dopaminergic neurones undergo terminal differentiation. In the adult rat, GDF-5 was found to be restricted to heart and brain, being expressed in many areas of the brain, including striatum and midbrain. This indicates a role for GDF-5 in the development and maintenance of dopaminergic neurones.

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