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J Neural Transm. 1999;106(2):139-44.

Midbrain dopaminergic neurons are protected from radical induced damage by GDF-5 application. Short communication.

By: Lingor P, Unsicker K, Krieglstein K.

Embryonic day 14 rat midbrain cultures were kept for 7 days in vitro and then intoxicated with radical donors iron and sodium-nitroprusside for 24 h. Tyrosine-hydroxylase positive neurons in cultures which were additionally treated with growth/differentiation factor-5 (GDF-5) survived to a significantly higher percentage as compared to sister cultures without factor supplementation. Since the degeneration of TH positive cells is a key feature in Parkinson's disease, GDF-5 might be a putative therapeutical agent for this disorder.


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